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Health Talk: How Paracetamol Causes Liver Damage

paracetamol liver damage

February 1st, 2017 – Health Talk: Taking Too Much Paracetamol Causes Acute Liver Failure 

  • Scientists have alerted that taking too much paracetamol is dangerous to health, especially to the liver.
  • These are the findings of a study published in ‘Scientific Reports’. According to the researchers, paracetamol overdose is the most common cause of liver failure in the United Kingdom, UK.
  • The researchers have therefore advised people who have taken more than the recommended maximum dose to go to their nearest accident and emergency (A&E) department as soon as possible.

Paracetamol is used to treat pain and fever. It is typically used for mild to moderate pain. Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

Although, it is generally safe at recommended doses, but too high a dose could result in liver failure, the study showed. Reacting to the development, Professor Nelson of Edinburgh University in the UK, said that although considered safe at therapeutic doses, it is quite easy to take too much paracetamol- so users should monitor their intake very carefully.

He said the drug can damage the liver by harming vital structural connections between adjacent cells in the organ. Professor Nelson of Edinburgh University, said: “Paracetamol is the most widely used over-the-counter and prescription analgesic worldwide.”

Around 200m packets are sold annually, accounting for two-thirds of the UK market for over-the-counter painkillers. He said: “When recommended doses of paracetamol are exceeded, acute liver failure can occur – and is the most common cause of ALF in the UK, United States, U.S, Europe and Australia.

“With a narrow therapeutic index, the common dose of paracetamol is close to the overdose, and given that it is found in many prescription and over-thecounter preparations, users need to monitor their intake closely.” He said that the underlying mechanisms of liver injury from paracetamol remain largely unclear.

“We describe a previously unknown effect of paracetamol on certain structural components liver tissue called tight junctions – or cell adhesions. – Professor Nelson explained:

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  1. Big Aunty Koks

    February 1, 2017 at 6:29 AM

    Most drugs are poisonous. Even in the places drugs are manufactured you find a section labelled “poison”. A medical personnel once said that it is better to allow the human body….antibodies…. Fight ailments sometimes rather than swallow medicine always. Perhaps that is why so many medical people are not enamoured with taking drugs! But what is the alternative when you feel unwell? It is a situation described as”between the devil and the deep blue sea”. May God help us!


    February 1, 2017 at 7:00 AM


  3. Bench

    February 1, 2017 at 7:14 AM

    Big Anty Koks make I tell you wetin you are doesn’t knows. If odinary human beans is dey between devil and deep blue sea, the persin is fear and also afred. But if na Jonah, he no go fear. He go just jump inside the sea make fish swallow him. The fish go vomit him for the front of his house and he go just tell the fish bye bye.

  4. fifelomo

    February 1, 2017 at 8:42 AM


  5. Jilo

    February 1, 2017 at 7:30 PM

    Increase in the rate of kidney disease in Nigeria may be as a result using toxic pain relief medines. I have said it before that certain malaria or fever drugs may cause kidney damage. The liver and kidney work with each other. If you have a liver damage, your kidney is already affected vice versa.

    The function of kidney in our body is to regulate and clean the blood and take it back into our body. If ones liver is damaged, there is a problem. We need to caution about how we use pain killer medicine. If at all we feel it is necessary to use them, we can take them in low dose for example using 100mg instead of 500 mg. it appears the way these medicines were manufactured is too lethal. The side effects outweigh its benefits. We may try to incorporate natural painkiller foods more into our foods instead of focusing on pain relief medicine. The following natural pain killer foods help to curb pain in our body; Garlic, Orange, Tumeric, Ginger, Cloves, Grape etc.

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